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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA2 All Species: 22.12
Human Site: Y623 Identified Species: 40.56
UniProt: Q9BZC7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BZC7 NP_001597 2435 269873 Y623 S L P P H V H Y K I R Q N S S
Chimpanzee Pan troglodytes XP_001152577 2346 264166 F570 Q A D D M A N F D W R D I F N
Rhesus Macaque Macaca mulatta XP_001117819 2476 273629 Y650 S L P P H V H Y K I R Q N S S
Dog Lupus familis XP_537788 2395 264756 Y623 S L P P H V H Y K I R Q N S S
Cat Felis silvestris
Mouse Mus musculus P41234 2434 270490 Y622 S L P P H V H Y K I R Q N S S
Rat Rattus norvegicus Q9ESR9 2434 270910 Y623 S L P P H V H Y K I R Q N S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 G545 W A G I V F T G V A P D S V E
Chicken Gallus gallus XP_422330 2276 256293 I555 A G V V F P D I D P T R K S L
Frog Xenopus laevis NP_001089022 2363 267334 Y569 N I P S H V K Y K I R M D I D
Zebra Danio Brachydanio rerio NP_001139161 2268 254351 S547 I V F P D M Q S N T S D L P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394
Sea Urchin Strong. purpuratus XP_798273 1913 213253 H192 K S L G L L L H V L F S R P T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 L160 F H E Q G P H L F D Y S I R L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.1 96 82.2 N.A. 91 92.9 N.A. 39.1 35.7 36.5 37.7 N.A. N.A. N.A. 23.7 41.7
Protein Similarity: 100 52 96.6 86.1 N.A. 93.2 94.9 N.A. 55.7 53.5 54.7 54.5 N.A. N.A. N.A. 39 54.4
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 0 6.6 46.6 6.6 N.A. N.A. N.A. 0 0
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 6.6 20 66.6 20 N.A. N.A. N.A. 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. 26.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 16 0 0 0 8 0 0 0 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 8 0 8 0 16 8 0 24 8 0 8 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % E
% Phe: 8 0 8 0 8 8 0 8 8 0 8 0 0 8 0 % F
% Gly: 0 8 8 8 8 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 47 0 47 8 0 0 0 0 0 0 0 % H
% Ile: 8 8 0 8 0 0 0 8 0 47 0 0 16 8 0 % I
% Lys: 8 0 0 0 0 0 8 0 47 0 0 0 8 0 0 % K
% Leu: 0 39 8 0 8 8 8 8 0 8 0 0 8 0 24 % L
% Met: 0 0 0 0 8 8 0 0 0 0 0 8 0 0 0 % M
% Asn: 8 0 0 0 0 0 8 0 8 0 0 0 39 0 8 % N
% Pro: 0 0 47 47 0 16 0 0 0 8 8 0 0 16 0 % P
% Gln: 8 0 0 8 0 0 8 0 0 0 0 39 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 54 8 8 8 0 % R
% Ser: 39 8 0 8 0 0 0 8 0 0 8 16 8 47 39 % S
% Thr: 0 0 0 0 0 0 8 0 0 8 8 0 0 0 8 % T
% Val: 0 8 8 8 8 47 0 0 16 0 0 0 0 8 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _